Clinical Epidemiology, Biostatistics & Literature Evaluation Course


Faculty:

  • Anthony J. Busti, MD, PharmD, FNLA, FAHA

Topics Covered


Introduction to Clinical Research & Literature Interpretation

  • Intro Lecture on Topics Covered & How to Use

Study Design, Development, & Interpretation

  • Hypothesis Testing
  • Study Design
  • Type of Bias in Research
  • Internal & External Validity

The Basics of Biostatistics - Part 1

  • General Overview - What is the Endpoint?
  • Measures of Central Tendency, Variability, & Dispersion
  • Types of Study Groups: Related or Independent Groups
  • Nominal, Ordinal, vs Continuous Data
  • Parametric vs. Nonparametric Statistical Analysis

    The Basics of Biostatistics - Part 2

    • Power
    • Alpha value
    • Confidence Intervals
    • P-values
    • Relative Risk, Absolute Risk, & Odds Ratio
    • Correlations & Coefficient of Variation
    • Regression Analysis

    Diagnostic Tests: Properties & Evaluation

    • Precision and Accuracy
    • Sensitivity & Specificity
    • Receiver Operator Characteristic (ROC)
    • Positive & Negative Predictive Values
    • LIkelihood Ratios

    Systematic Reviews & Meta-Analyses

    • What is the Difference Between Them?
    • Key Steps Involved
    • Reporting the Results - The Forest Plot
    • The GRADE Assessment
    • Reporting Guidelines & Critical Appraisal

    Clinical Literature, Evaluation & Critical Appraisals

    • Reporting Guidelines of Studies
    • Critical Appraisal Tools
    • Assessment for Bias in Publications

    Special Topics

    • Pharmacoeconomic Analysis
    • FDA New Drug Approval Process
    • Medication Errors Reporting and Safety
    • HIPPA Review
    • Medication Therapy Management
    • Disease State Management